CBD & The Endocannabinoid System

How CBD Interacts with the Body & Endocannabinoid System


CBD is the primary active ingredient in hemp. It’s one out of hundreds of similar compounds, called cannabinoids, that are produced by the cannabis plant family. CBD is simultaneously one of the most powerful and least psychoactive cannabinoids. CBD is short for cannabidiol, though it’s not an acronym. Cannabidiol has been shortened to CBD because it’s customary for cannabinoids to be represented by three letter abbreviations, like THC for tetrahydrocannabinol or CBG for cannabigerol. Cannabidols support the endocannabinoid system to keep all of your body’s functions in check.

What Are Cannabinoids? Cannabinoids are active compounds produced by all cannabis plants and by all living humans.

Technically, there are two types of cannabinoids:

Endocannabinoids: Cannabinoids produced internally, by the human body.

Phytocannabinoids: Cannabinoids produced by plants.

PCR hemp, for example, contains many phytocannabinoids. In addition to cannabidiol (CBD), there are cannabichromene (CBC), cannabigerol (CBG) and Cannabidivarin (CBdv). Like CBD, CBC is non-psychoactive.

What Do Endocannabinoids Do?

Endocannabinoids are cannabinoids produced by us, for us. They serve as signaling molecules, or neurotransmitters, that help the body communicate within itself.

Many neurotransmitters are produced by the nervous system in response to things like health levels and environmental factors. They interact with and send messages to receptors found on the surfaces of cells. Their primary job is to help cells adjust their activities.

In order to illustrate how neurotransmitters work, let’s use an analogy. The brain doesn’t connect with every cell in your body, just like traffic officers don’t connect directly with every car on the road.

Your body’s endocannabinoid system (ECS) connects to a wide variety of sensors to keep track of every system in your body.

In both cases, that means some messages have to be relayed. In the case of managing traffic, we implement traffic signals. These signals inform drivers where they can and cannot travel, when they should stop and when they should go, how fast they are allowed to move, and so on.

Some of these signals can sense what’s going on in the environment — such as when a car pulls up to a traffic light. The sensor triggers a controller causing the light to change, thereby changing the behavior of drivers approaching that intersection.

In the same way, your body’s endocannabinoid system (ECS) connects to a wide variety of sensors to keep track of every system in your body. The signals from these sensors are decoded by the brain and the nervous system. If it’s determined that a system has gone out of balance, the ECS releases neurotransmitters into areas that need the most help.

The Human Endocannabinoid System

Now that we understand how neurotransmitters work to adjust our cellular activity, let’s take a look at the role endocannabinoids play in maintaining homeostasis, or balance, within the body.

The human endocannabinoid system (ECS) has two components: endocannabinoids, and endocannabinoid receptors which pick up their signals.

CBD Endocannabinoid System

In a sense, the endocannabinoid system actually motivates us to exercise.

Endocannabinoids are unique in that they’re produced directly from the fat-based cell membranes of nerve and brain cells. This resourcefulness means endocannabinoids can be produced quickly — basically on demand — wherever the body needs them. In other words, endocannabinoids are as natural as you can get.

CBD helps the ECS produce greater amounts of endocannabinoids in the areas where they’re needed. One of these endocannabinoids, called anandamide, is responsible for the production and uptake of serotonin. Serotonin is a neurotransmitter responsible for mood and anxiety

Often referred to as the “bliss molecule”, anandamide’s impact on serotonin levels directly improves one’s mental state. While serotonin levels are often low in people suffering from depression, those with a healthy ECS usually produce plenty of serotonin.

This biochemical ‘cross-talk’ means that exercise is excellent for the endocannabinoid system health. Exercise, especially prolonged exercise, delivers an influx of new endocannabinoids into the brain, causing a better stress response and a more dynamic metabolism.

In fact, recent evidence shows that endocannabinoids (eCB’s) are to thank for “runner’s high,” that post-workout euphoria we’ve grown to know and love. Once thought to be caused by endorphins, it turns out that endorphin molecules are much too large to actively enter the brain. eCB’s, on the other hand are small and easily activate the brain’s ‘feel-good’ receptors. In a sense, the endocannabinoid system actually motivates us to exercise.

But does this mechanism flow both ways? If exercise is good for endogenous cannabinoids… are plant cannabinoids like CBD good for exercise?

The answer is definitely yes. CBD fosters several improvements in athletic performance.

In general, the endocannabinoid system is vast and far- reaching. It regulates a wide array of bodily functions, from appetite regulation to sleep patterns, moods, metabolism, immune response, the lifespan of cells, and much more. This is the reason that CBD seems to effect such a wide range of conditions.

Read more in-depth information on the ECS on the NIH website.

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